Absence of evidence for MHC-dependent mate selection within HapMap populations.

Absence of evidence for MHC-dependent mate selection within HapMap populations.

Blog Article

The major histocompatibility complex (MHC) of immunity genes has been reported to influence mate choice in vertebrates, lightning to usb apple and a recent study presented genetic evidence for this effect in humans.Specifically, greater dissimilarity at the MHC locus was reported for European-American mates (parents in HapMap Phase 2 trios) than for non-mates.Here we show that the results depend on a few extreme data points, are not robust to conservative changes in the analysis procedure, and cannot be reproduced in an equivalent but independent set of European-American mates.

Although some evidence suggests an avoidance of extreme MHC similarity between mates, rather than a preference tumbler lid that holds liquor for dissimilarity, limited sample sizes preclude a rigorous investigation.In summary, fine-scale molecular-genetic data do not conclusively support the hypothesis that mate selection in humans is influenced by the MHC locus.